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Research in decerebrate male rat models further supports the role of the caudal brainstem in GLP-1-mediated cardiovascular responses, where hindbrain-restricted GLP-1R activation was sufficient to suppress food intake while inducing tachycardia, independent of hypothalamic or forebrain input (28)
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The Congressional Budget Office has estimated that covering the drugs would cost Medicare about $35 billion from 2026 to 2034
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