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16 , 17 The M1 phenotype is associated with the release of cytokines and mediators that amplify inflammation and promote neurotoxicity, whereas the M2 phenotype suppresses inflammation and fosters tissue repair

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While both compounds drive appetite suppression and insulin sensitization through GLP-1 and GIP pathways, Retatrutide’s GCGR activity delivers three additional effects: direct hepatic fat mobilization, increased thermogenesis, and accelerated lipid oxidation