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In α-cells, the TATA box, as well as the adjacent G1 and G4 elements, represent the minimal promoter which is essential for Gcg expression while the elements G5, G2, G3, and CRE represent a more distal located enhancer region [94,[101], [102], [103]] (Figure 2)
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When we applied the same methods used in the GLP-1 analysis, these drugs showed no difference in fracture risk between the exposure and non-exposed patients
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